Plaquenil guidelines for eye monitoring 2016

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  1. Renenet New Member

    Plaquenil guidelines for eye monitoring 2016


    Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating.

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    My Take on New Ocular Screening Guidelines for Plaquenil By Sergio Schwartzman, MD 12 October 2016 A recent article published by the American Academy of Ophthalmology AAO presented new recommendations for screening of patients being managed with hydroxychloroquine HCQ. What is Plaquenil or hydroxychloroquine? Hydroxychoroquine is an oral medication used for the treatment of rheumatologic conditions like lupus systemic lupus erythematosus – SLE, rheumatoid arthritis and other inflammatory conditions. Highlights of the 2016 guidelines in­clude the following. Use real body weight. “The bottom line is that the daily dose should be 5.0 mg per kg or less, using real body weight,” said Michael F. Marmor, MD, at Stanford University in Palo Alto, Calif.

    Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area).

    Plaquenil guidelines for eye monitoring 2016

    Despite Plaquenil dosing recommendations, retinal toxicity., Plaquenil - Eye Doctor MD

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  7. To date, there are no data demonstrating that monitoring blood levels of HCQ is useful in dosing 34 HCQ to prevent retinal toxicity. 35 36 In addition to dose and duration of therapy, other factors must be considered when prescribing 37 HCQ and making recommendations about monitoring.

    • AMERICAN COLLEGE OF RHEUMATOLOGY.
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    We just need to get better at monitoring the eyes and dosing Plaquenil correctly.” New dosing guidelines for Plaquenil, which Lyons worked on, were published in the journal Ophthalmology. Thomas is enthusiastic about the updated guidelines, although he worries that the new dosing recommendations have not been widely disseminated to. The latest screening guidelines were published in 2016 by the American Academy of Ophthalmology Table 1. The most important risk factors are dosage and duration of use. Dosage greater than 5.0mg/kg over five years dramatically increases the risk of retinal toxicity, and high doses can be exceedingly dangerous. Aug 30, 2011 Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2.

     
  8. drezdenIKS New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine diphosphate Autophagy Inhibitor MedChemExpress Chloroquine - FDA prescribing information, side effects and uses Chloroquine phosphate MSDS Search our.
     
  9. BonaHost.ru XenForo Moderator

    Hydroxychloroquine Oral Route Description and Brand Names. Description and Brand Names. Drug information provided by IBM Micromedex US Brand Name. Plaquenil; Descriptions. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work.

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  10. promotek User

    Methotrexate Lab Tests Online A methotrexate test is typically ordered at regular intervals e.g. at 24 hours, 48 hours, and at 72 hours as needed after administration of high-dose methotrexate. Tests to monitor blood cell counts and kidney and liver function are also ordered at regular intervals during methotrexate therapy.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More