One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. What does hydroxychloroquine cost Chloroquine keratopathy Doxycycline rosacea and plaquenil Later in the disease, patients can develop a bilateral bull's eye maculopathy, characterized by a ring of retinal pigment epithelium RPE depigmentation in the macula, sparing the fovea, which is often accompanied by paracentral and central scotomas. End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. Plaquenil Toxicity both Eyes - Partial Bull's Eye - Discontinued 6 Years ago 1042 views 82-year-old woman was on Plaquenil from 1976 from 2005, 200 mg a day. It was discontinued because of abnormal visual fields 6 years ago. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil bull's eye maculopathy Multimodal Imaging in Plaquenil Toxicity, Bull's-eye maculopathy due to hydroxychloroquine toxicity Plaquenil for crest syndromePlaquenil cost per pillHydroxychloroquine drugs.com Retinal toxicity associated with chronic exposure to hydroxychloroquine and its ocular screening. Review. the diffuse loss of fundus pigmentation makes the bull’s eye maculopathy hard to recognize. Severns ML. Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity a review of mfERG ring ratios in Plaquenil. Retinal toxicity associated with chronic exposure to.. Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy.. Plaquenil Related Eye Problems - Fraser Eye. The presence of bull’s-eye maculopathy indicates the disease has been progressing for years, resulting in foveal thinning and likely vision loss. 8 SD-OCT is a highly sensitive and reproducible imaging modality used in the detection of Plaquenil retinal toxicity. The preferential loss of photoreceptor IS/OS junction makes SD-OCT an ideal tool. Bull's eye maculopathy. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. During your yearly eye examination your eye doctor is looking for changes called "Bulls Eye Maculopathy". These are pigmentary changes typically in a target or ring pattern occurring right at the central vision area. Rarely enough, I have had a patient with confirmed plaquenil maculopathy.