Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine 200 mg tab generic plaquenil Hydroxychloroquine 中文名 Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion Fig 12-15. A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties. Does Patient with Lupus Have Plaquenil Retinopathy? 1. Falcone PM, Paolini L, Lou PL. Hydroxychloroquine toxicity despite normal dose therapy. Ann Ophthalmol 1993 Oct ; 2510385-8. 2. Weisinger HS, Pesudovs K, Collin HB. Management of pa-tients undergoing hydroxychloroquine Plaquenil therapy. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil corneal verticillata Chloroquine And Hydroxychloroquine Toxicity - StatPearls., Corneal verticillata Tylenol and plaquenil The aminoquinoline antimalarial drugs amodiaquine, chloroquine, mepacrine quinacrine, and hydroxychloroquine Plaquenil® are another common cause of drug-induced corneal deposits. Hydroxychloroquine is frequently used in the United States to treat rheumatoid arthritis and lupus erythematosus. Drug-induced corneal epithelial changes - ScienceDirect. Does Patient with Lupus Have Plaquenil Retinopathy?. Cornea Verticillata - EyeWiki. Plaquenil side effects start off by effecting the surface of the eye the cornea leading to verticillata. Verticillata are deposits of salts within the corneal epithelium. This does not cause any symptoms to the patient and is reversible when the medication is stopped. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage.