Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine proguanil Chloroquine diphosphate salt chem-impex Hydroxychloroquine and lupus On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Bull's-eye maculopathy due to hydroxychloroquine toxicity. Contributor Jesse Vislisel, MD Photographer Randy Verdick, FOPS September 9, 2013. This patient took hydroxychloroquine for rheumatoid arthritis and her vision dropped to 20/300 as a result of the retinal toxicity. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity macula Plaquenil Risk Calculators, The Risk of Retinal Toxicity with Plaquenil - Sjogren's Aralen costoChloroquine phosphate degradation My DIL says that some docs are not well versed in Plaquenil toxicity and they can panic and take people off the Plaquenil when there is no toxicity. There is a fine line between toxicity and some other eye issues the ways she explains it. I guess with your eye problem and taking the Plaquenil it might be prudent to get all the info that is out. Plaquenil eye toxicity versus macular degeneration. Bull's-eye maculopathy due to hydroxychloroquine toxicity. Plaquenil Toxicity - Bennett & Bloom Eye Centers. The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Management when they are seeing patients who are on or about to begin Plaquenil. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes.