Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine 500mg tab Chloroquine rapamacyin Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Medicines that may cause Plaquenil interactions include digoxin, cyclosporine, and mefloquine. This eMedTV resource contains a more detailed list of drugs that may interact with Plaquenil and describes the potential effects of these interactions. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil methotrexate interactions Methotrexate and Proton Pump Inhibitors, Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Plaquenil skin pigment Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. Hydroxychloroquine Side-effects, uses, time to work. Plaquenil Interactions - Antibiotics Home Page. Hydroxychloroquine oral and methotrexate sodium oral Drug.. Co-administration of PLAQUENIL with other antimalarials known to lower the convulsion threshold e.g. mefloquine may increase the risk of convulsions. Antiepileptics The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. Methotrexate Combined use of methotrexate with PLAQUENIL has not been studied and may Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.