I currently take 6 tablets a week and I started taking them in February this year . Has anyone been through the same as me, and find that the meds simply haven't worked so you have to simply start again. I have called my nurse specialist but she hasn't got back yet. Hang in there- it's very early days x I'm afraid Jacki08 is right it's early days and these meds take time. I am still in a lot of pain I have immense fatigue and feel miserable. I started MTX in September along with naproxen and gradually built up to 8 tablets (20mg) a week by the end of December. Plaquenil and eggs Plaquenil toxicity in macular oct layer changes What is chloroquine sulphate used for Dosage Hydroxychloroquine Plaquenil® is the drug of choice among antimalarials. Chloroquine is not commonly used because of greater toxicity on the eye. Chloroquine is not commonly used because of greater toxicity on the eye. What next if plaquenil doesn't work? Support Forums. I have to have liver and crp retest next week. My hair is coming out slightly Not in clumps are anything, just a little here or there. Really though in order not to have worse things happen it is what we have to do. I know it is scary but anything to stop the pain and misfunction of not. Quinacrine Atabrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the patient does not respond to Plaquenil alone. Things have been in their stride since mid February and now it's looking good regarding fatigue, swelling and pain (though I only ever had a little pain compared to what others have described). I started taking mthx in October last year and expected results quite quickly. Hydroxychloroquine not working what next Enbrel not working, anyone tried orencia?, What next if plaquenil doesn't work? Chloroquine emcChloroquine 750 mgCan you rheumate with plaquenilChloroquine chemistryPct and hydroxychloroquine mechanism Hi ya, I remember the frustration at the beginning, they started me on 8 tablets, didn't do much for 4 months so upped me to 10, after another 3-4 months it did start to help watch out for mouth ulcers, mine were horrendous, needed 6 x folic acid tablets a week to keep them at bay. Methotrexate not working so what next? Hi everyone as.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. If after three months on the first anti-TNF biologic the patient still does not show improvement, then it is recommended to switch to another anti-TNF or a non anti-TNF. These non anti-TNFs include Orencia, Actemra, and Rituxan. If after six months there is not a positive response. Hiya, sorry to hear you are not feeling any benefit from yr meds yet, but im sure others will tell you its still early days yet as you only started them in february, its needs a lil bit more time to build up and get working yet.x Medication Uses How To Use Side Effects Precautions Drug Interactions Overdose Notes Missed Dose Storage. USES Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant.