I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Chloroquine during pregnancy Carbamazepine with chloroquine Chloroquine syrup dosage for infants Hi honey, YES.stopping plaquenil for a couple of days can cause symptoms to arise or get worse.needs to be taken exactly as prescribed. Twice a day, every day. Missing one dose wont make a major difference but skipping more then one, or days absolutely can. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Stopping plaquenil Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Rx Side Effects New Plaquenil Guidelines and More - American. Leflunomide hydroxychloroquine combinationHow does azathioprine work with plaquenil for lupusHydroxychloroquine kidney side effectsPlaquenil toxicity ideal body weight Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Taking Plaquenil for Rheumatoid Arthritis. Plaquenil Withdrawal – Life As An Anomaly. If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you. Jun 19, 2013 It didn't take me long to feel the effects of stopping. I guess I didn't realize how much it was helping me. So far I feel More tired Breathing is more difficult Feels like I am drowning Arms and legs are tingling Numb hands and feet Headache I don't know if this is the result of stopping Plaquenil or just how my Sarcoidosis is presenting. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.