Estrogen use should be discontinued unless its need outweighs its adverse effects on porphyrin metabolism. After achievement of remission, estrogen therapies may be cautiously reinstituted; however, the duration of remissions may be shortened. Hydroxychloroquine used for Hydroxychloroquine brand name Chloroquine phoenix cells Phyria, and porphyria cutanea tarda, all of which are implicated in neurologic disease except for porphyria cutanea tarda. The three hepatic porphyrias with poten-tial neurologic manifestations are all autosomal domi-nant disorders and all present with acute attacks of illness. Another type of hepatic porphyria, caused by Porphyria Cutanea Tarda PCT is the most common of the Porphyrias and results from a deficiency of the enzyme uroporphyrinogen decarboxylase UROD. Porphyria Cutanea Tarda PCT is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin photosensitivity. Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure. If symptoms recur, re-treatment can restore remissions. Remissions may last from several months to many years. Why hydroxychloroquine for porphyria cutanea tarda Hydroxychloroquine treatment of porphyria cutanea tarda., Porphyria Cutanea Tarda PCT - American Porphyria Foundation Hydroxychloroquine arthritis research Porphyria cutanea tarda may appear for the first time in patients with end-stage renal disease after several months of long-term dialysis. Anuric individuals can be readily diagnosed by assaying a plasma or serum specimen for the characteristic elevated levels of polycarboxylated porphyrins. Porphyria Cutanea Tarda Treatment & Management Medical.. Hydroxychloroquine MedlinePlus Drug Information. Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment.. Porphyria cutanea tarda PCT typically is acquired rather than inherited, although the enzyme deficiency may be inherited. Certain triggers that impact enzyme production — such as too much iron in the body, liver disease, estrogen medication, smoking or excessive alcohol use — can cause symptoms. Porphyria cutanea tarda PCT is a rare disease, with a strong association with hepatitis C virus. PCT is particularly problematic in end-stage renal disease patients as they have no renal excretion of porphyrins and these are poorly dialyzed. Plaquenil hydroxychloroquine Disease Interactions. There are 8 disease interactions with Plaquenil hydroxychloroquine The use of 4-aminoquinolines is generally considered contraindicated in the presence of retinal or visual field changes, whether attributable to 4-aminoquinoline compounds or to any other etiology.