Chloroquine and cancer stem cells

Discussion in 'Canadian Pharmacy' started by EmbetteSespab, 17-Mar-2020.

  1. Sene4ka User

    Chloroquine and cancer stem cells


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    In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activityhigh “superpotent cancer stem cells” spCSCs. The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1. Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling Article PDF Available in Molecular Cancer Therapeutics 137 April 2014 with 251 Reads Triple negative breast cancer TNBC is known to contain a high percentage of CD44 + /CD24 −/low cancer stem cells CSC, corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine CQ, an anti-malarial drug, is a lysotropic reagent which inhibits autophagy.

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    Chloroquine and cancer stem cells

    Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of., PDF Chloroquine Targets Pancreatic Cancer Stem Cells via.

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  4. Up until recently, inhibitory effects of chloroquine on the late stage of autophagy was thought to be the major mechanism underlying cancer cells death from chloroquine. However, recent research provided compelling evidence that autophagy-inhibiting activities of chloroquine are dispensable for its ability to suppress tumor cells growth.

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    Triple negative breast cancer TNBC is known to contain a high percentage of CD44 +/CD24 −/low cancer stem cells CSCs, corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine CQ, an antimalarial drug, is a lysotropic reagent which inhibits autophagy. Pancreatic cancer cell line PaTu II 12, the effects of chloroquine on tumor growth were later. confirmed in mouse models of PDAC and attributed to the inhibition of autophagy 13, which is. responsible for recycling bioenergetic components to ensure cell survival in nutrient-deprived. times or locations 13. Triple negative breast cancer TNBC is known to contain a high percentage of CD44 +/CD24 −/low cancer stem cells CSC, corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine CQ, an anti-malarial drug, is a lysotropic reagent which inhibits autophagy.

     
  5. andr3w-1 User

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  6. Atikova Well-Known Member

    Signs of hydroxychloroquine toxicity in a patient with. A spectral domain-optical coherence tomography SD-OCT was performed that showed changes in the outer retina in the eye with macular detachment, as well as the “flying saucer” sign in the other eye. After a complete retinopexy the “flying saucer” sign was still present.

    Spectral domain optical coherence tomography as an effective.