However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case of twin sisters who both suffered from systemic lupus erythematosus (SLE) and HCQ-induced cardiomyopathy presenting with decompensated heart failure (HF), suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy. Plaquenil bradycardia Chloroquine read yamde sigma Malaria tablets chloroquine and proguanil side effects Hydroxychloroquine eye test Hydroxychloroquine myopathy is thought to be underestimated with prior reports noting normal CK levels in patients with typical biopsy features of vacuoles and curvilinear bodies. Duration of drug and dose are not well defined in myopathy; onset of symptoms may vary months to years; typical symptoms are nonspecific mild to moderate proximal muscle weakness with slightly elevated to normal CK levels. Electron microscopy revealed disorganized myofibrils, abundant vacuoles, multiple lamellar inclusion bodies, and curvilinear cytoplasmic bodies, findings that are pathognomonic for hydroxychloroquine-induced restrictive cardiomyopathy Figure. Hydroxychloroquine was discontinued, and the patient started on guideline directed heart failure therapy. The curvilinear bodies are comma-shaped structures which in human pathology occur only in cases of CQ damage and in neuronal ceroid lipofuscinosis, a group of hereditary neurodegenerative disorders in children 7,8,40. While curvilinear bodies definitively document the pathogenesis of CQ toxicity, the presence of lamellar inclusion bodies is also described after the administration of amiodarone and in other storage diseases 41. Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use (1). Hydroxychloroquine (HCQ) is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases (1). Curvilinear bodies hydroxychloroquine cardiomyopathy Chloroquine‐induced cardiomyopathy a reversible cause of., Hot hearts on bone scintigraphy are not all amyloidosis. Plaquenil long term side effectsAralen priceAbruptly stopping plaquenil HCQ neuromyotoxicity is a rare complication characterized by proximal muscle weakness, normal creatinine kinase levels, and characteristic ultrastructural changes on muscle biopsy of curvilinear body formation. Hydroxychloroquine-induced toxic myopathy causing respiratory.. Cardiomyopathy Caused by Longterm Treatment with Chloroquine.. Dilated Cardiomyopathy and Hydroxychloroquine-induced.. Hydroxychloroquine HCQ, a common anti-rheumatic medication, can be cardiotoxic and cause systolic or diastolic heart failure HF. A 65 year old man presented with acute decompensated HF. He had a history of rheumatoid arthritis, and had been treated with hydroxychloroquine for the last 8 years. Abstract. Chloroquine Hydroxychloroquine-induced cardiomyopathy is a rare but potentially life-threatening condition. Cessation of the culprit drug, along with aggressive afterload reduction therapy, has been associated with halting of disease progress and even improvement in patients' clinical and histologic status. Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy key diagnostic features and literature review. Curvilinear bodies in particular appear to be the most specific histological indicator of antimalarial-related cardiotoxicity and these structures are not seen in differential diagnoses of some of.