Curvilinear bodies hydroxychloroquine cardiomyopathy

Discussion in 'Canadian Pharmacy' started by yrtimd, 07-Mar-2020.

  1. maximusk Well-Known Member

    Curvilinear bodies hydroxychloroquine cardiomyopathy


    However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case of twin sisters who both suffered from systemic lupus erythematosus (SLE) and HCQ-induced cardiomyopathy presenting with decompensated heart failure (HF), suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy.

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    Hydroxychloroquine myopathy is thought to be underestimated with prior reports noting normal CK levels in patients with typical biopsy features of vacuoles and curvilinear bodies. Duration of drug and dose are not well defined in myopathy; onset of symptoms may vary months to years; typical symptoms are nonspecific mild to moderate proximal muscle weakness with slightly elevated to normal CK levels. Electron microscopy revealed disorganized myofibrils, abundant vacuoles, multiple lamellar inclusion bodies, and curvilinear cytoplasmic bodies, findings that are pathognomonic for hydroxychloroquine-induced restrictive cardiomyopathy Figure. Hydroxychloroquine was discontinued, and the patient started on guideline directed heart failure therapy. The curvilinear bodies are comma-shaped structures which in human pathology occur only in cases of CQ damage and in neuronal ceroid lipofuscinosis, a group of hereditary neurodegenerative disorders in children 7,8,40. While curvilinear bodies definitively document the pathogenesis of CQ toxicity, the presence of lamellar inclusion bodies is also described after the administration of amiodarone and in other storage diseases 41.

    Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use (1). Hydroxychloroquine (HCQ) is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases (1).

    Curvilinear bodies hydroxychloroquine cardiomyopathy

    Chloroquine‐induced cardiomyopathy a reversible cause of., Hot hearts on bone scintigraphy are not all amyloidosis.

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  5. HCQ neuromyotoxicity is a rare complication characterized by proximal muscle weakness, normal creatinine kinase levels, and characteristic ultrastructural changes on muscle biopsy of curvilinear body formation.

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    Hydroxychloroquine HCQ, a common anti-rheumatic medication, can be cardiotoxic and cause systolic or diastolic heart failure HF. A 65 year old man presented with acute decompensated HF. He had a history of rheumatoid arthritis, and had been treated with hydroxychloroquine for the last 8 years. Abstract. Chloroquine Hydroxychloroquine-induced cardiomyopathy is a rare but potentially life-threatening condition. Cessation of the culprit drug, along with aggressive afterload reduction therapy, has been associated with halting of disease progress and even improvement in patients' clinical and histologic status. Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy key diagnostic features and literature review. Curvilinear bodies in particular appear to be the most specific histological indicator of antimalarial-related cardiotoxicity and these structures are not seen in differential diagnoses of some of.

     
  6. asteises Guest

    The standard method of diagnosis is by reverse transcription polymerase chain reaction (r RT-PCR) from a nasopharyngeal swab. Chloroquine Dreams Segundo Mes Chloroquine Indications, Side Effects, Warnings - Plaquenil Oral Uses, Side Effects, Interactions, Pictures.
     
  7. Arhitrade New Member

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil is most often well-tolerated but, like with any drug, side effects are possible. Most people about 90% who take antimalarial medications experience no side effects. If common side effects do occur, they are usually minor and last only for a short period of time.

    Plaquenil – RheumInfo
     
  8. reallife Guest

    Chloroquine Oral Route Proper Use - Mayo Clinic Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor.

    Effects of chloroquine on viral infections an old drug.