I have been found that I have seriously low platelet levels and was wondering if this drug plaquenil could have something to do with it. My mom used this drug for treating symptoms of rheumatoid arthritis. I say "treated" because I never was placed on any medication and my treatment consisted of regular CBC's to count my platelets, which ranged from 28,000 three years ago to 125,000 in April. Fda hydroxychloroquine Chloroquine phosphate 500 mg dosage Aug 14, 2017 According to the New Zealand Dermatological Society, Plaquenil can cause abnormalities in blood counts. An abnormally low number of white blood cells can lead to infection, because white blood cells defend the body against bacteria. Low platelet count thrombocytopenia can lead to easy bleeding and bruising. In people with RA, thrombocytopenia may be mild and cause few signs or symptoms. If the platelet count drops beneath a certain threshold, the inability to clot will manifest with increasingly obvious symptoms. In rare cases, the platelets may be so low that internal bleeding occurs. The drug-induced thrombocytopenia, mechanical destruction of the platelets, and hemodilution are common causes of low platelet count encountered after open heart surgery. 1 Although drug-induced immune thrombocytopenia has a mild clinical course in most cases, in this case it was severe may depend of cross-reaction between acetyl salicylic acid and hydroxychloroquine. I was fortunate to have to switch hemotologists in April because my new Hemo did some additional tests which suggested Lupus. I was dx with Lupus in May, after being "treated" for idiopathic thrombocytopenia purpura for three and a half years. Plaquenil low platelets Plaquenil and low wbc - Things You Didn’t Know, How Rheumatoid Arthritis Affects Platelets Can you take plaquenil and ibuprofenHydroxychloroquine and sun sensitivitySmall bowel obstruction bowel obstruction take hydroxychloroquine The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C 18 H 26 ClN 3 O. H 2 SO 4. Plaquenil hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients Dibasic calcium phosphate USP. Plaquenil - FDA prescribing information, side effects and uses. A case of thrombocytopenia associated with the use of.. Low platelet count thrombocytopenia Causes, treatment.. PLAQUENIL should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Dermatologic Effects. Dermatologic reactions to PLAQUENIL may occur and, therefore, proper care should be exercised when it is administered to any patient receiving a drug with a significant tendency to produce dermatitis. Im also on Plaquenil once a day now instead of 2 cause they can cause platelets to be low as well so they reduced that. Thanks so much and sorry so long Brandi. renalupie1 responded My mother had many many health issues. It may come to that since Ive been having symptoms of the low platelets for about a few months unknowingly, but the. A low platelet count called thrombocytopenia refers to an abnormally low number of platelets, the particles in blood that help with clotting. As a result, blood does not clot normally. As a result, blood does not clot normally.