Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil pigmentation treatment Hydroxychloroquine lyme supplements Hydroxychloroquine retinopathy cumulative dose Mechanism of Action Unknown; may interfere with with macrophage presentation of antigen to T cells Contraindications Hypersensitivity to hydroxychloroquine, chloroquine, or 4-aminoquinolines Precautions Use caution in hepatic disease, psoriasis, and porphyria. Lupus Systemic Lupus Erythematosus or SLE Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. Hydroxychloroquine HCQ is an antimalarial agent that has been used in systemic lupus erythematosus SLE and rheumatoid arthritis RA treatments for many years. Recently, advances in our understanding of its mechanisms of action have expanded the therapeutic prospects of HCQ 1–3. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine mechanism of action in sle Mechanism of action of hydroxychloroquine as an., Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Plaquenil and shortness of breath Hydroxychloroquine, an antimalarial drug, is traditionally used in the treatment of SLE. Its effectiveness in treating APS has been previously questioned. In vitro and in vivo studies showed a beneficial effect of hydroxychloroquine on thrombosis 121–124. Hydroxychloroquine - an overview ScienceDirect Topics. Hydroxychloroquine decreases Th17-related cytokines in.. Aralen chloroquine Malaria Drug Side Effects & Dosage. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Antiprotozoal-Malaria /Mechanism of action/ may be based on ability of chloroquine to bind and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.