Chloroquine mechanism of action in sle

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  1. lir666 User

    Chloroquine mechanism of action in sle


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mechanism of Action Unknown; may interfere with with macrophage presentation of antigen to T cells Contraindications Hypersensitivity to hydroxychloroquine, chloroquine, or 4-aminoquinolines Precautions Use caution in hepatic disease, psoriasis, and porphyria. Lupus Systemic Lupus Erythematosus or SLE Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. Hydroxychloroquine HCQ is an antimalarial agent that has been used in systemic lupus erythematosus SLE and rheumatoid arthritis RA treatments for many years. Recently, advances in our understanding of its mechanisms of action have expanded the therapeutic prospects of HCQ 1–3.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action in sle

    Mechanism of action of hydroxychloroquine as an., Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria

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  3. Hydroxychloroquine, an antimalarial drug, is traditionally used in the treatment of SLE. Its effectiveness in treating APS has been previously questioned. In vitro and in vivo studies showed a beneficial effect of hydroxychloroquine on thrombosis 121–124.

    • Hydroxychloroquine - an overview ScienceDirect Topics.
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    • Aralen chloroquine Malaria Drug Side Effects & Dosage.

    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Antiprotozoal-Malaria /Mechanism of action/ may be based on ability of chloroquine to bind and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

     
  4. Ewgenia XenForo Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. PLAQUENIL Dosage & Rx Info Uses, Side Effects Introduction to Fluoroquinolone Antibiotics. Hydroxychloroquine - Wikipedia
     
  5. Hydroxychloroquine - Wikipedia One of the most serious side effects is a toxicity in the eye generally with chronic use. People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams.

    Hydroxychloroquine Sulfate Drug Information, Professional
     
  6. emilasp New Member

    Plaquenil and Quinine drug interactions - eHealthMe Summary Drug interactions are reported among people who take Plaquenil and Quinine together. This study is created by eHealthMe based on reports of 52 people who take Plaquenil and Quinine from Food and Drug Administration FDA, and is updated regularly.

    Hydroxychloroquine - Wikipedia