Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil and anesthesia Hydroxychloroquine and lung cancer Treatment of uncomplicated malaria due to Chloroquine-sensitive Plasmodium species Adults An initial dose of 1 g salt = 600 mg base followed by an additional 500 mg = 300 mg base after six to eight hours and a single dose of 500 mg = 300 mg base on each of two consecutive days. Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences. Both drugs are concentrated in erythrocytes and 55% of chloroquine and 98% of mefloquine in plasma is bound to protein. The pharmacokinetics of chloroquine are complex and, because of the extremely long β phase, difficult to accurately define. Pyrimethamine t½ 35 to 175 hours has more limited tissue distribution. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Chloroquine poisoning treatment Chloroquine and Hydroxychloroquine Toxicity Treatment., Chloroquine and Hydroxychloroquine • LITFL • Toxicology. Plaquenil pediatric dose for sleChloroquine autophagyChloroquine mechanism of drug action and resistance in plasmodium falciparumPlaquenil and astIs plaquenil a steroid Hydroxychloroquine is synthesized by adding a hydroxy group to the parent compound, chlorquine. 1 According to animal studies, chloroquine is 2 to 3 times more toxic than hydroxychloroquine. 8 There is much more toxicologic experience with chloroquine as it is a common method of attempting suicide in Africa and France.9, 10 It is also commonly prescribed as treatment for malaria, lupus, and rheumatoid arthritis, and accidental ingestions in children have been reported. The drug has a very. Treatment of hydroxychloroquine overdose - ScienceDirect. PDF Chloroquine poisoning - ResearchGate. Chloroquine Side Effects Common, Severe, Long Term.. Hydroxychloroquine – which has a similar toxicity profile – has largely superseded it for the treatment of rheumatoid arthritis. In overdose both chloroquine and hydroxychloroquine cause sodium channel blockade with primarily cardiovascular and central nervous system effects, as well as hypokalemia due to intracellular potassium shifts. Depending on the specific disease, patients may be treated with either a chronic maintenance or acute high-level dose of chloroquine. A daily dose of chloroquine 3 mg/kg and a treatment duration of 5 years are considered important risk factors for the development of retinopathy. https//gov/pmc/articles/PMC3913974/ Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.