Alternatively, we suggest using this opportunity to take a little break from work and read some of the interesting articles below. Description: An exception occurred while processing your request. H-chloroquine Chloroquine resistant malaria treatment in children Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times. Accumulation of the drug may result in deposits that can lead to blurred vision and blindness. Potassium eﬄux blocker toxicity Background Medications in the Kþ eﬄux blocker category are listed in Table 1. These medications all block the outward ﬂow of potassium from intracellular to extracellular spaces. Myocardial repolarization is driven predominantly by this outward movement of potassium ions 3. Chloroquine (Nivaquine) was the first drug used for the treatment of malaria. Additionally, another exception occurred while executing the custom error page for the first exception. Chloroquine toxicity ecg PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION, Chloroquine - Wikipedia Literature review of chloroquine syrupAf plaquenilWhat if i accidentally take 2 plaquenilOregano oil and plaquenilIs plaquenil safe for pregnancy The antimalarial agents chloroquine CQ and hydroxychloroquine HCQ are used in long-term treatment of connective tissue diseases CTDs. A high incidence of heart conduction disorders, including bundle-branch block and incomplete or complete atrioventricular block, has been observed among patients treated with CQ. Heart conduction disorders related to antimalarials toxicity.. ECG Manifestations The Poisoned Patient. The cardiotoxicity of antimalarials. I know that these drugs are notorious to cause ECG abnormalties like QTc prolongation caused by via sodium channel blockade as well as hypokalemia due to intracellular potassium shifts. I've seen data that shows an average of +25ms and up to +50ms on the ECG for chloroquine. QTc prolongation can result in no symptoms as far as sudden death. Screening to detect antimalarial-related cardiotoxicity early is prudent. The monitoring of ECG and echocardiography is recommended for patients with long term treatment of HCQ. The risk factors for HCQ-induced cardiotoxicity have not been identified due to limited number of cases reported. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus.