It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Chloroquine lysosomal degradation Plaquenil dosage sjogren's syndrome Hydroxychloroquin cardiac protective Half-Life 70–120 h. Nursing Implications. Assessment & Drug Effects. Monitor for therapeutic effectiveness; may not appear for several weeks, and maximal benefit may not occur for 6 mo. Do baseline and periodic ophthalmoscopic examinations and blood cell counts on all patients on long-term therapy. Pharmacokinetics Following a single 200 mg oral dose of hydroxychloroquine sulfate tablets to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Half life of hydroxychloroquine sulfate Plaquenil hydroxychloroquine sulfate dose, indications., DailyMed - HYDROXYCHLOROQUINE SULFATE tablet Intravenous chloroquine injection Hydroxychloroquine has been shown to cause severe hypoglycaemia including loss of consciousness that could be life threatening in patients treated with and without antidiabetic medications. Patients treated with hydroxychloroquine should be warned about the risk of hypoglycaemia and the associated clinical signs and symptoms. Plaquenil 200mg Film-coated Tablets - Summary of Product.. Plaquenil Hydroxychloroquine Sulfate. Bioavailability of hydroxychloroquine tablets in healthy.. Hydroxychloroquine is usually available as the sulfate salt with hydroxychloroquine constituting about 75% of the labeled dose of hydroxychloroquine sulfate. It has a half-life of over a month. Some studies have not been clear about the salt form and dosage of the products being taken and others have sampled milk after only a few doses before. Hydroxychloroquine is a prescription drug. It comes as an oral tablet. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version. It is available in 200 mg tablets of hydroxychloroquine phosphate each containing 155 mg of hydroxychloroquine. 1 Although commonly used in the treatment of rheumatologic diseases, it is a rare source of overdose in the United States. However, life-threatening symptoms can occur within an hour of ingestion.