Pharmacokinetics of quinine chloroquine and amodiaquine

Discussion in 'Cheap Chloroquine' started by blast123, 24-Feb-2020.

  1. ifti Well-Known Member

    Pharmacokinetics of quinine chloroquine and amodiaquine

    It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles.

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    The quinoline antimalarials quinine, chloroquine, amodiaquine, primaquine and mefloquine comprise the majority of world antimalarial drug usage. These compounds have narrow therapeutic ratios. None of them is younger than twenty years old. The object of this article is to illustrate howthe treatmentofmalaria. As quinine is a lipophilic drug and has low hepatic clearance with a narrow therapeutic index, significant alterations in the pharmacokinetics of quinine in obese individuals might have clinical implications with respect to dosage regimens in obese patients. Chloroquine CQ, a 4-aminoquinoline compound, has been used for the prophylaxis and treatment of malaria. It acts on the ring forms of the parasites, which are relatively resistant to the action of quinine 23.

    People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes.

    Pharmacokinetics of quinine chloroquine and amodiaquine

    Pharmacokinetic Interactions between Primaquine and Chloroquine, Pharmacokinetics of quinine in obesity - ScienceDirect

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  3. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during

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    Clinical Pharmacokinetics of Zidovudine. Pharmacokinetics of Quinine, Chloroquine and Amodiaquine. Dr Sanjeev Krishna, Nicholas J. White Pages 263-299. Chloroquine, noncurative, and amodiaquine, partially curative, have nearly the same initial dose-independent killing with a lag phase of minimal parasite reduction at all doses between 6 and 24. There was no measurable long terminal elimination phase, and the principal metabolite desethyl amodiaquine was not detected in the plasma samples. There was no serious toxicity in either group. During intravenous injection there was a significant fall in systolic blood pressure in four subjects mean fall 16 mm Hg but there was no significant change in heart rate. ABSTRACT TRUNCATED AT 250 WORDS

  4. averichevigor New Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Arthritis Medications and Hair Loss Arthritis Foundation Had anyone used plaquenil or hydroxychloroquine 2
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    Hydroxychloroquine User Reviews for Rheumatoid Arthritis. User Reviews for Hydroxychloroquine to treat Rheumatoid Arthritis Also known as Plaquenil, Quineprox The following information is NOT intended to endorse any particular medication.

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