He reported a history of tick bite and rash in 2002. The knee pain and other symptoms rapidly improved over the next two weeks. He received a short course of antibiotics at that time. After two weeks he reported that the antibiotics were causing nightmares and insomnia. Then one week later he complained of confusion and unsteadiness. Sle plaquenil with methotrexate Hydroxychloroquine kidney side effects Plaquenil is often perceived as an anti-arthritis drug used to treat connective tissue disorders. What it does is make the body more alkaline. My doc explained that he prescribes it with Biaxin Clarithromycin-an intracellular abx because by making the body more alkaline, the Biaxin can more easily penetrate the body's cells, which makes it up to 40% more effective. Minocycline, Plaquenil, Worse Symptoms A few weeks ago my doctor's appointment was enlightening. We were happy with my progress, discussing removing the PICC line soon, and working on getting me back into school. Jul 05, 2010 I was switched to a different anti-biotic regimen almost four weeks ago to treat chronic Lyme disease neuroborreliosis clarithromycin and hydroxychloroquine. I haven't been feeling as well since, having more fatigue, itchy skin, lightheadedness and myoclonus. He continued to improve rapidly once more with a cessation of neurocognitive symptoms. When I saw him initially he complained of knee pain and swelling, fatigue, generalized arthralgia (joint pain), numbness and tingling and an irregular heart beat. I diagnosed a "brain Herx." I added Plaquenil back, as well as Welchol, presumptively to remove "neurotoxins." I also reduced the dose of Amoxicillin and Minocin. Plaquenil dosage for lyme disease LymeMD Plaquenil alone?, Elaina's Lyme Disease Story Minocycline, Plaquenil, Worse. Hydroxy chloroquine 400 mgBrazil nuts and plaquenilHydroxychloroquine normal dose rangeHydroxychloroquine liver toxicityH-chloroquine 200mg Oct 06, 2017 Plaquenil hydroxychloroquine "I felt better than I have in 20 years! After 20 years on NSAIDS needed for Lyme arthritis, my kidneys were affected, and when I stopped NSAIDS cold turkey, it was amazing how much pain my body was in. Now a year into Plaquenil I feel like a new person. Get eyes checked every 6 months. Hydroxychloroquine User Reviews for Lyme Disease, Arthritis.. Clarithromycin and hydroxychloroquine Plaquenil - LymeNet.. How effective is Plaquenil for Lyme disease by duration.. Lori, I'm not medically trained, but here's what I find on the internet for your consideration Plaquenil is a drug used to treat malaria and also in autoimmune conditions such as lupus and rheumatoid arthritis. The references I have found as to using it in Lyme treatment combine Plaquenil with another medication at the same time. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. How long to treat patients with Lyme remains an issue of controversy. With traditional antibiotic therapy, lasting 2-4 weeks, 10-20% of patients will have ongoing symptoms including fatigue, joint.