Please review the following URL and make sure that it is spelled correctly. Hi everybody, I was wondering if Plaquenil's primary mode of action was to suppress the immune system? Plaquenil drug eruption Dosage of chloroquine in chikungunya Diagnosis code for plaquenil therapy Lupus is an auto-immune disease in which the immune system cannot distinguish between threats like viruses and bacteria, and healthy cells and tissue. As a result, the body produces antibodies that inflict cell damage, most commonly targeting joints, skin, kidneys and the nervous system. Join the group and find support for coping with lupus. Summary Immunodeficiency disorders is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months, also take medication Humira, and have Mixed connective tissue disease. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree. 1 month ago and prior to taking it I rarely ever got sick with colds,flu etc. I am asking this question, because I started this med approx. Plaquenil and immune system Anyone on Hydroxychloroquine plaquenil - Autoimmune diseases - Inspire, Will you have Immunodeficiency disorders with Plaquenil - eHealthMe Plaquenil toxicity screening recommendationsGeneric vs brand plaquenil1989 honduras chloroquineChloroquine toxicity in eyePlaquenil hydroxychloraquine doseage Re want to know good stuff about plaquenil Sorry to be a party pooper here, but I have been on Plaquenil for 5 months and can't say I feel any difference at all. If anything I am sleeping all day but for just about 1 1/2 hours at a time. Immune & Autoimmune - Lupus want to know good stuff about plaquenil. Methotrexate Does it weaken my immune system?. Plaquenil and Enbrel - Arthritis - Inspire. Any one have any experience or info regarding pre-existing precancerous conditions and the effects of Plaquenil on the immune system. I see so much info on the net where some says that Plaquenil has very mild effect on immune system except for eye issues --- Other info says it is an immunosuppressant. I've been on Plaquenil for almost 2 wks now and I'm also taking Prednisone, could one of these be causing my extreme stomach cramps? 2 nights ago, I had a cheeseburger and mac and cheese and I thought I was going to die about 1 in the morning. I ended up throwing up once and then I had diarrhea for a bit and then it passed once my system cleared. There is evidence that hydroxychloroquine may interfere with communication between cells in the immune system. This action suppresses the normally overactive immune response in lupus patients which may explain one reason Plaquenil works so well for those suffering with lupus.