Hydroxychloroquine qt prolongation

Discussion in 'Chloroquine Phosphate' started by stepanenko, 21-Feb-2020.

  1. G.K. Guest

    Hydroxychloroquine qt prolongation


    The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened.

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    Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences. Hydroxychloroquine may cause a condition that affects the heart rhythm QT prolongation. QT prolongation can rarely cause serious rarely fatal fast/irregular heartbeat and other symptoms such as severe dizziness, fainting that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Heart problems like heart failure and a certain abnormal heartbeat prolonged QT interval have happened with hydroxychloroquine. Sometimes, these heart problems have been deadly. Call your doctor right away if you have a fast or abnormal heartbeat; very bad dizziness or passing out; or shortness of breath, a big weight gain, or swelling in.

    The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used.

    Hydroxychloroquine qt prolongation

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  4. Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia. Clin Toxicol Phila. 2006; 442173-5 ISSN 1556-3650 Chen CY; Wang FL; Lin CC. BACKGROUND Hydroxychloroquine HCQ is used for treatment of lupus erythematosus. The cardiac toxicity of HCQ has focused primarily on acute intoxication.

    • Chronic hydroxychloroquine use associated with QT..
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    HS34-HS40. ABSTRACT QT prolongation is a rare adverse event associated with many drugs, including antipsychotics and antidepressants. The majority of cases have occurred in patients taking an offending agent with multiple identifiable risk factors for corrected QT QTc prolongation. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Metabolism of a QT-prolonging drug or by causing an electrolyte disturbance that induces TdP Drugs to Avoid in Congenital Long QT. These drugs pose a high risk of TdP for patients with CLQTS and include all those in the above 3 categories PLUS additional drugs that do not prolong the QT but have a special risk because of their actions

     
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  6. Titanium Well-Known Member

    Hydroxyzine Oral Route Side Effects - Mayo Clinic Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve the symptoms of an allergic reaction eg, hives, itching skin caused by chronic urticaria, and atopic and contact dermatoses.

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