Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Trametinib hydroxychloroquine Plaquenil and low neutrophils Plaquenil dosage for osteoarthritis Introduction Antimalarials have been recognized as effective drugs for the treatment of articular and cutaneous manifestations of systemic lupus erythematosus SLE, but its potential in the management of systemic features of the disease has not yet been thoroughly evaluated. Objectives This study intended to evaluate the efficacy of chloroquine diphosphate CDP in preventing flares and in. Several cases of hypopigmentation of the skin have been reported. Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine systemic lupus erythematosus Lupus Systemic Lupus Erythematosus Guide Causes., Chloroquine Side Effects Common, Severe, Long Term. High risk meds plaquenil icd 10Leflunomide and hydroxychloroquine A variety of antimalarial medications have been shown to be effective for systemic rheumatic diseases since quinine was first used to treat systemic lupus erythematosus SLE more than 100 years ago. Three of these drugs are now primarily used due to their safety profile. Chloroquine and hydroxychloroquine HCQ are 4-aminoquinoline derivatives. UpToDate. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Chloroquine treatment influences proinflammatory cytokine.. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Although chloroquine is sometimes used, the preferred antimalarial drug is hydroxychloroquine due to its greater safety. These drugs are not painkillers. Seizures as a rare adverse effect of chloroquine therapy in systemic lupus erythematosus patients a case report and literature survey Piotr Krzeminski, 1 Aleksandra Lesiak, 2 and Joanna Narbutt 2 Systemic lupus erythematosus; treatment; disease activity; We thank Drs Figueroa-Parra et al for their interest in our paper1 and their comment regarding the value of chloroquine CQ as an alternative antimalarial in systemic lupus erythematosus SLE.2 As the authors point out, there are data, mostly for older studies, to support the efficacy of CQ in SLE.3 Nevertheless, over the last 20.