It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Shared care guidelines hydroxychloroquine Chloroquine phosphate 250 mg base Sle and plaquenil Plaquenil discount program Plaquenil can cause edema in the feet and legs. One of the warnings says to contact your doctor if you develop swelling/edema in the feet and legs. I had a medication cause me to retain fluid and I gained 6.5 pounds in 2 days. All of it was in my legs and feet. Heavy legs and edema in the ankles occur due to vascular insufficiency. Monitor your diet and eliminate salt when possible. This leads to swelling in the ankles and high-blood pressure. Keeping your legs above your heart helps maintain the flow of venous blood. Heavy legs and edema may be secondary to another illness such as diabetes. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Can plaquenil cause edema The Risk of Retinal Toxicity with Plaquenil, How to Avoid Having Heavy Legs & Swelling of Ankles. Msds chloroquine phosphateStopped plaquenil lymphomaPlaquenil toxicity visual fieldWhat will happen if i don't take plaquenilPlaquenil treat lupus Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Rx Side Effects New Plaquenil Guidelines and More.. Swollen feet and plaquenil Anti-Inflammatories.. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Corneal changes including edema and opacities can be symptomless or may cause disturbances such as haloes, blurring of vision or photophobia. They may be transient and are reversible when therapy is discontinued.-Maculopathies and macular degeneration can occur from 3 months to several years of exposure to this drug and may be irreversible.