It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. What tier is plaquenil Chloroquine for malaria Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. I have been prescribed Plaquenil 400 mg daily to see if there is any improvement in my fatigue etc. I have been told the most common side effects of Plaquenil are increased sun sensitivity, nausea and sometimes eye problems. But after doing a bit of reading, it seems hair loss can sometimes be an issue with this medication as well. As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs. PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil lethargy Is extreme fatigue a side effect of Plaquenil?, UCTD and Plaquenil DailyStrength Side effects plaquenil weight gainPlaquenil rash skinAffect of hydroxychloroquine Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long- term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Is extreme fatigue a side effect of Plaquenil - NRAS. Chronic fatigue is a serious and debilitating condition, and it's often found among those with rheumatoid arthritis. Experts don't entirely understand the relationship between the two, but they have some ideas how they're connected. Common side effects Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. Dizziness Precautions with this side effect Do not drive, use machinery. Cramps. Headache. Dry skin. Loss of appetite. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.