Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Block mhc chloroquine Plaquenil normal dosage SD-OCT is an objective test for toxicity that complements 10-2 visual field testing. 10-2 visual testing is probably more sensitive, but is heir to interpretational difficulties and variability not so much a problem with SD-OCT. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. drug toxicity, hydroxychloroquine, photoreceptors. Normal Spectralis spectral domain optical coherence tomography SD OCT image with intact photoreceptor inner segment/outer segment junction. Plaquenil Toxicity both Eyes - Partial Bull's Eye - Discontinued 6 Years ago SD-OCT Spectral domain optical coherence tomography 2320 views 82-year-old woman was on Plaquenil from 1976 from 2005, 200 mg a day. It was discontinued because of abnormal visual fields 6 years ago. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct image plaquenil toxicity Retina Today - Evaluating Hydroxychloroquine Toxicity With., Spectral domain optical coherence tomography as an. Eyes hydroxychloroquineChloroquine target proteinPlaquenil side effects weight H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Retinal Physician - Hydroxychloroquine Maculopathy An.. Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy.. Plaquenil Toxicity - Retina Image Bank. Our patient demonstrates the importance of using the new recommended screening tools for the detection of early hydroxychloroquine toxicity. 10-2 HVF, SD-OCT, autofluorescence, or mfERG might have detected the hydroxychloroquine retinal toxicity on the day of her presenting symptoms and possibly earlier, potentially limiting the amount of visual loss. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1.