Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. Hydroxychloroquine making sunlight painful Plaquenil and metoprolol Chloroquine proguanil dosage Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. Thank you for your interest in spreading the word about Science. Chloroquine action Chloroquine Oral Uses, Side Effects, Interactions., Chloroquine - FDA prescribing information, side effects and uses Plaquenil and kidneys Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Chloroquine C18H26ClN3 - PubChem. Chloroquine Oral Uses, Side Effects, Interactions, Pictures.. Chloroquine - Wikipedia. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Pharmacol Ther. 1993 Feb-Mar;572-3203-35. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Of note, chloroquine and hydroxychloroquine are considered to be safe and side-effects are generally mild and transitory. However, the margin between the therapeutic and toxic dose is narrow and chloroquine poisoning has been associated with cardiovascular disorders that can be life-threatening Frisk-Holmberg et al. 1983. Chloroquine and.