It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Safe to take plaquenil with antacids Plaquenil et alcool Hydroxychloroquine and breastfeeding Plaquenil skin rash side effects My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? Mar 24, 2011 no methotrexate doesn't always mean your hair will fall out or thin but some of the side effects are scary, but before you an progress onto other meds methotrexate is mandatory. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them. Hey everyone! Is anyone here with psoriatic arthritis just taking plaquenil or sulfasalazine or both together? I’m curious to know if these drugs can individually or mutually be enough to control inflammatory symptoms. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. What to use when plaquenil and sulfasalazine doesn't work How Does Plaquenil Work For Rheumatoid Arthritis, What next if plaquenil doesn't work? - Plaquenil photosensitivityHydroxychloroquine dosage for osteoarthritisPlaquenil spottingHydroxychloroquine drug card Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. Any success with plaquenil or sulfasalazine? PsoriaticArthritis. Rheumatoid Arthritis Drug Treatments Pros and Cons.. Aug 22, 2006 Optimal use of disease‐modifying antirheumatic drugs DMARDs in rheumatoid arthritis is vital if progression of disease is to be reduced. Methotrexate MTX and sulfasalazine SASP are widely used inexpensive DMARDs, recently often combined despite no firm evidence of benefit from previous studies. What are the side effects of hydroxychloroquine and sulfasalazine in treating rheumatoid arthritis? ANSWER Hydroxychloroquine Plaquenil and sulfasalazine Azulfidine are used for mild. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems.