Tamoxifen 5 years versus 10 years

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    Tamoxifen 5 years versus 10 years


    Breast cancer is the most common type of cancer in women around the world, and the second leading cause of cancer deaths among U. For women whose breast cancer is diagnosed before it has spread, the 5-year survival rate is 99%. The survival rate for early-stage breast cancer is very high. For women whose breast cancer has spread to the lymph nodes, the 5-year survival rate is 85%. Women who are diagnosed with early-stage breast cancer almost always undergo surgery to remove the cancer (either lumpectomy/partial mastectomy or mastectomy). Most will also choose at least one other treatment in addition to surgery: 1) If they have a lumpectomy, they often undergo radiation either to shrink the tumor before surgery or to kill any cancer cells in the breast that were missed during surgery. 2) If their cancer is estrogen receptor positive (about 84% of breast cancers), many women will try to take hormonal therapy for at least five years after surgery to lower the chance of cancer in either breast in the future. For pre-menopausal women, the standard treatment is tamoxifen.[1] Hormonal therapy (also called endocrine therapy or anti-estrogen therapy) is the opposite of the type of hormones women sometimes take to reduce the symptoms of menopause. Margaret Andrews couldn’t wait to be done with hormonal therapy: treatment for hormone receptor-positive breast cancer, which grows because of the hormones estrogen or progesterone. After a stage IIb breast cancer diagnosis in 1999, Margaret had surgery, chemotherapy and radiation therapy. She then began taking tamoxifen before switching to an aromatase inhibitor (AI). I was tired of muscle aches and sexual side effects,” says Margaret, 70, a retired teacher who lives in Hollis, Alaska. She thought she would be on the AI anastrozole (Arimidex) for 5 years, which quickly began to feel like a very long time. At her checkup in 2007, Margaret received some unexpected news: The oncologist recommended she take anastrozole for another 5 years. That was an unusual suggestion then, but early research was beginning to suggest women with hormone receptor-positive breast cancer might receive more protection from a new breast cancer or cancer coming back if they took hormonal therapy beyond the usual 5 years. Margaret says she and her husband “were so disappointed because we were looking forward to the time when I could be off it.” But she decided to continue hormonal therapy. Many women with hormone receptor-positive, early-stage breast cancer face the same choice Margaret did.

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    Aug 7, 2014. ATLAS randomized 12,894 women between 19 with early breast cancer to continue tamoxifen for 10 years versus stopping at 5. Continuing tamoxifen for 10 years versus stopping at 5 years reduced breast cancer recurrence 16.7% vs 19.3%; P=.003 and breast cancer. Mar 20, 2013. The absolute increased risk of death from endometrial cancer in women who took tamoxifen for 10 years versus 5 years was 0.2 percent.

    Before these studies came out, most premenopausal women diagnosed with early-stage, hormone-receptor-positive breast cancer took 5 years of tamoxifen therapy to lower the risk of recurrence. Premenopausal women take tamoxifen and postmenopausal women have a choice between tamoxifen or an aromatase inhibitor such as Arimidex (chemical name: anastrozole), Aromasin (chemical name: exemestane), or Femara (chemical name: letrozole). Now, the ATLAS and a TTOM results are starting to change treatment standards for early-stage, hormone-receptor-positive breast cancer. Being cancer-free 5 years after diagnosis is a big milestone for cancer patients. That’s when we start using the word “cure.” That’s partially why earlier studies on tamoxifen used 5 years as a treatment time period. Still, we know that women can have breast cancer recurrences 7 years, 8 years, 10 years, or more after diagnosis. That’s one reason doctors wanted to see if taking tamoxifen for a longer time would offer more benefits. But should all women diagnosed with early-stage, hormone-receptor-positive breast cancer take tamoxifen for 10 years? While many, many women will benefit from 10 years of tamoxifen, there is a group that would do better with another type of treatment. For some women with breast cancer, taking adjuvant tamoxifen (Nolvadex®) for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial. The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium (SABCS) and published in on December 5, 2012—are likely to change clinical practice, several researchers said. Nearly 7,000 women with early-stage, estrogen receptor-positive breast cancer were enrolled in the trial between 19. After taking tamoxifen for 5 years, participants were randomly assigned to continue taking tamoxifen for another 5 years or to stop taking it. From 5 to 9 years after the women began tamoxifen therapy, there was little difference in outcomes between the two treatment groups. This finding is consistent with those from other trials of adjuvant tamoxifen therapy, which showed that 5 years of tamoxifen can substantially reduce the risk of the cancer returning and of cancer death in the next few years, what one of the trial investigators, Richard Gray, MSc, of Oxford University, UK, called a "carryover effect." The improved outcomes with longer tamoxifen use emerged only after the 10-year mark, Gray explained during an SABCS press briefing. Among the women who took tamoxifen for 10 years, the risk of breast cancer returning between 10 and 14 years after starting tamoxifen was 25 percent lower than it was among women who took it for 5 years, and the risk of dying from breast cancer was nearly 30 percent lower.

    Tamoxifen 5 years versus 10 years

    ATTom Long-term effects of continuing adjuvant tamoxifen to 10., Tamoxifen 5 years vs 10 - Из Бумаги - iz-

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  5. Anybody else coming up to or been through 5 years of tamoxifen following breast cancer? 5 years used to be the gold standard but new research is saying 10.

    • Tamoxifen 5 years versus 10 years - Mumsnet.
    • Ten Years of Tamoxifen Reduces Breast Cancer Recurrences..
    • Another Study Shows 10 Years of Tamoxifen Better Than 5 for Early..

    Jun 1, 2018. However, women who took tamoxifen for 5 years had a 0.6% chance per year. aged 45-54 years who took tamoxifen died from breast cancer within 10 years of. Aromatase inhibitors versus tamoxifen in early breast cancer. Jan 30, 2017. aTTom Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer. In 20, large studies found that 10 years of tamoxifen. trial of additional 2 versus additional 5 years of anastrozole after initial 5.

     
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