It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine phosphate injection dosage Effects of stopping plaquenil May 13, 2009 The anti-malarial drugs Hydroxychloroquine HCQ is widely used to treat various rheumatic diseases mechanism of action of this drug is to increase the pH in acidic vesicles, inhibiting receptor mediated endocytosis that affects many cellular functions including antigen presentation, toll receptor signaling and post-transcriptional modification of proteins 2–4. Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. Two women who had taken hydroxychloroquine 200 mg probably sulfate equivalent to 150 mg of base once or twice daily the report is unclear before and during pregnancy had milk levels measured after delivery. Hydroxychloroquine levels in the two mothers were 3 mcg/L at unspecified times after a dose. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Pregnancy hydroxychloroquine Plaquenil Hydroxychloroquine during pregnancy., Hydroxychloroquine Use During Pregnancy Plaquenil dosage for arthritisHydroxychloroquine flu vaccineHydroxychloroquine main side effect Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Hydroxychloroquine MedlinePlus Drug Information. Hydroxychloroquine - Safe In Breastfeeding. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Stars. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births. 1Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands. 2Department of Gynecology and Obstetrics, University Medical Center Utrecht, Utrecht, Netherlands.