Long-term progression of hydroxychloroquine retinopathy off the drug marmor

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  1. victorino XenForo Moderator

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    We found that a pericentral pattern of HCQ retinopathy was predominant among Korean patients, rather than the traditional bull's eye parafoveal pattern of damage. Retinopathy progressed while on the drug, but the progression stopped in patients with toxicity detected before RPE damage. Marmor MF, Hu J. Effect of disease stage on progression of hydroxychloroquine retinopathy. JAMA Ophthalmol. 2014 Sep. 132 91105-12. Kellner S, Weinitz S, Farmand G, Kellner U. Cystoid macular oedema and epiretinal membrane formation during progression of chloroquine retinopathy after drug cessation. Purpose To characterize the stability or progression of different stages of hydroxychloroquine HCQ retinopathy up to 20 years after stopping the drug. Methods We reviewed findings from 13 patients with initial HCQ retinopathy classified as early patchy photoreceptor damage, moderate ring of photoreceptor thinning or scotoma, or severe retinal pigment epithelial RPE damage.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    How Safe Is Long-Term Hydroxychloroquine?, Chloroquine and Hydroxychloroquine Toxicity Clinical.

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  7. Corneal toxicity presents as an intraepithelial deposition of the drug into the cornea, which rarely affects vision. Ciliary body dysfunction disturbs accommodation and is rare. Risk Factors. Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use.

    • Hydroxychloroquine toxicity - EyeWiki.
    • SEQUENTIAL CHANGES IN HYDROXYCHLOROQUINE RETINOPATHY UP TO 20..
    • Michael Marmor, MD's Profile Stanford Profiles.

    The potential for chloroquine phosphate and hydroxychloroquine sulfate retinopathy to progress after cessation of the drug has long been recognized, 1 - 4 primarily in patients with severe ring scotoma or a visible bull’s-eye lesion in the fundus. Such progression could continue for many years after the drug was stopped. Retinal Toxicity Progression. Severe HCQ retinopathy often progresses even after drug cessation Researchers used multimodal imaging to study retinal and vision changes after hydroxychloroquine HCQ cessation in 22 patients with HCQ retinal toxicity. Progression of Hydroxychloroquine Toxic Effects After Drug Therapy Cessation New Evidence From Multimodal Imaging. and long-term follow-up of patients with hydroxychloroquine retinopathy.

     
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