One class of medications can lead to more severe vision loss in people with the wet form of the disease, and another class of drugs may have a beneficial effect. Fortunately, very few prescription drugs have any known detrimental effects for people with AMD. Can hydroxychloroquine cause a false positive for pregnancy Ran out of hydroxychloroquine Drusen. The appearance of drusen — yellow deposits — in the retina indicates the development of early-stage dry macular degeneration left. As the condition progresses to the advanced stage right, the drusen get larger, bleeding occurs and the light-sensitive cells that make up the macula become scarred. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. The investigators think that there is a connection between the use of plaquenil and the prevention of Age related macular degeneration AMD. The investigators believe that the use of plaquenil makes bruch's membrane thicker, thereby preventing Chroidal Neovascularization CNV growth. Doctors often put patients with certain potentially life-threatening cardiovascular conditions on this blood thinner. Warfarin (Coumadin®), which is an anticoagulant blood thinner, is one exception. Using plaquenil in end stage macular degeneration Retinal Physician - Hydroxychloroquine Maculopathy An Update., Methotrexate, Plaquenil or Sulfasalazine Azulfidine. Hydroxychloroquine lupus treatmentHydroxychloroquine remission early onset rheumatoid arthritis What is Plaquenil or hydroxychloroquine? Hydroxychoroquine is an oral medication used for the treatment of rheumatologic conditions like lupus systemic lupus erythematosus – SLE, rheumatoid arthritis and other inflammatory conditions. Plaquenil - Eye Doctor MD. Plaqenil Role in Prevention of Age Related Macular Degeneration. Medication Cautions in Macular Degeneration - AMDF. Aug 16, 2012 Anyway I was diagnosed with dry macular degeneration 7 years ago. A recent exam showed it has worsened. I have also seen 3 rheumatologists, and 2 of them say I should take Plaquenil and the risk of damage to my macula is not big enough to not take the Plaquenil. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is.