It has been shown in multiple SLE populations to associate with improved survival (1-3) and specifically has been found to be effective in the treatment of cutaneous disease(4), arthritis(5), with an augmenting effect on the efficacy of mycophenolate mofetil in the management of nephritis(6) amongst other positive health effects(7, 8). Füzéry AK, Breaud AR, Emezienna N, Schools S, Clarke WA. Hydroxychloroquine is a safe, non-immunosuppressive therapy with good tolerability. A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry. Plaquenil and insomnia Chloroquine tablet for malaria Objectives To determine dosing patterns and examine predictors of filled hydroxychloroquine HCQ prescriptions in patients with systemic lupus erythematosus SLE with end-stage renal disease ESRD. Methods This was a retrospective cohort study of patients with SLE in the US Renal Data System USRDS database in fiscal year 2011. Usual Adult Dose for Rheumatoid Arthritis. -Initial dose 400 to 600 mg 310 to 465 mg base orally once a day to optimum response usually 4 to 12 weeks -Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; Patients were prescribed hydroxychloroquine not to exceed 6.5mg/kg max400mg/day. In hemodialysis, the dose was 200mg after each session, in renal insufficiency it was 200mg/day. Levels were measured at each visit with a therapeutic range of 500-2000 ng/ml. Patients were divided according to baseline blood level. There is also significant controversy surrounding how to best dose this medication, with some advocating dosing based on actual body weight (capped at 400 mg per day), whilst others are in favor of calculating the daily dose based on ideal body weight. Adherence to treatment in systemic lupus erythematosus patients. However, there are increasing concerns about retinopathy, in particular, in light of new screening methods, which are thought to have increased sensitivity(9). Costedoat-Chalumeau N, Pouchot J, Guettrot-Imbert G, Le Guern V, Leroux G, Marra D, et al. Hydroxychloroquine hemodialysis Dialyzable drugs - WikEM, Hydroxychloroquine Dosage Guide with Precautions - Plaquenil for lupus review inflammationIs hydroxychloroquine a steroidHydroxychloroquine for polymyalgia rheumaticaCan i drink if taking plaquenilPlaquenil dosage according to weight There is disagreement about dosing; rheumatologists recommend weight-based dosing while some other specialists advocate height-based “ideal body weight” dosing. Methods Patients were prescribed HCQ not exceeding 6.5 mg/kg max 400 mg/day. In hemodialysis, the dose was 200 mg after each session, and in renal insufficiency it was 200 mg/day. Hydroxychloroquine Blood Levels in Systemic Lupus.. Hydroxychloroquine Blood Levels in SLE Clarifying dosing.. Plaquenil hydroxychloroquine sulfate dose, indications.. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during Concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Monitoring Guidelines. Guidelines on screening for retinopathy associated with hydroxychloroquine toxicity were initially published by the Academy in 2002.