Begin 1-2 days before travel, daily during travel, and for 7 days after leaving. Factors that affect local malaria transmission patterns can change rapidly and from year to year, such as local weather conditions, mosquito vector density, and prevalence of infection. Hydroxychloroquine blindness Plaquenil and pulmonary hypertension Hydroxychloroquine erectile dysfunction Chloroquine in treatment of hypercalcemia Atovaquone/proguanil, sold under the trade names Malarone among others, is a combination of two antimalarial medication atovaquone and proguanil. It is used to treat and prevent malaria, including chloroquine-resistant malaria. It is not recommended for severe or complicated malaria. It is taken by mouth. Jun 01, 2019 Atovaquone and Proguanil hydrochloride tablets have been shown to be effective in regions where the drugs chloroquine, halofantrine, mefloquine, and amodiaquine may have unacceptable failure rates, presumably due to drug resistance. Atovaquone and Proguanil Dosage and Administration One case report was found on diving and mefloquine. Multiple case reports and clinical trials were found describing neurologic adverse effects of the major chemoprophylactic medications atovaquone/proguanil, chloroquine, doxycycline, mefloquine, and primaquine. Several medications are available for chemoprophylaxis. When deciding which drug to use, consider specific itinerary, length of trip, cost of drug, previous adverse reactions to antimalarials, drug allergies, and current medical history. Information in these tables is updated regularly.4. Atovaquone proguanil chloroquine doxycycline or mefloquine Prophylactic use of antimalarials during pregnancy, Atovaquone and Proguanil - FDA prescribing information, side. Can chloroquine go through skinStop antibodies drug plaquenilIs chloroquine safe in early pregnancy Doxycycline and atovaquone/proguanil provide protection within one to two days and may be better tolerated. If a person becomes ill with malaria despite prophylaxis with mefloquine, the use of halofantrine and quinine for treatment may be ineffective. 4. Malaria treatment Mefloquine - Wikipedia. Safety of antimalarial medications for use while scuba diving.. Malaria Prevention –. When chloroquine, doxycycline, or mefloquine is used for primary prophylaxis, primaquine is usually taken during the last 2 weeks of postexposure prophylaxis. When atovaquone-proguanil is used for prophylaxis, primaquine may be taken during the final 7 days of atovaquone-proguanil, and then for an additional 7 days. Weiss WR, Oloo AJ, Johnson A, et al. Daily primaquine is effective for prophylaxis against falciparum malaria in Kenya comparison with mefloquine, doxycycline, and chloroquine plus proguanil. J Infect Dis 1995; 169. Ohrt C, Richie TL, Widjaja H, et al. Mefloquine compared with doxycycline for the prophylaxis of malaria in Indonesian soldiers. Regarding the malaria tabs, I'm very limited in what I can take and the Malarone is my least worst option. I'm allergic to mefloquine, hate doxicycline because nobody should take unnecessary antibiotics for 6 weeks at a time, and the old chloroquine and paludrine also has proguanil.