Chloroquine effect on lysosomes

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  1. nvrskozzy Well-Known Member

    Chloroquine effect on lysosomes


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using chloroquine while you are pregnant. Preventing malaria We have identified two classes of lysosomes. Lighter lysosome- like vesicles, which are greatly enriched in acid phosphatase activity the marker enzyme of lysosomes, contain a great deal of binding activity. This PRL binding was only slightly increased by pretreatment of animals with the lysosomotropic agent chloroquine. Some side effects of chloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine effect on lysosomes

    Chloroquine - American Osteopathic College of Dermatology AOCD, Effect of Chloroquine on Lysosomal Prolactin Receptors in Rat.

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  4. In this study, ARPE-19 cells were treated with chloroquine to inhibit lysosomal function. Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively.

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    Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. The effect of chloroquine, an inhibitor of intralysosomal catabolism, on the synthesis, transport, and degradation of cell-coat glycoproteins in absorptive cells of cultured human small-intestine tissue was investigated by morphometrical, autoradiographical, and biochemical methods. Chloroquine has been used as an anti-malarial drug and is known as a lysosomotropic amine as well. The effects of chloroquine on lysosomal integrity in cultured rat hepatocytes were studied by.

     
  5. VirMaster User

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Aquarium Fish Chloroquine A "New" Drug for Treating Fish. Chloroquine Phosphate - Fish Medication Information - Algae. Breakthrough Chloroquine phosphate has shown apparent.
     
  6. Jupiter New Member

    Chloroquine induced involuntary movements. - Abstract. Europe PMC is an ELIXIR Core Data Resource Learn more. Europe PMC is a service of the Europe PMC Funders' Group, in partnership with the European Bioinformatics Institute; and in cooperation with the National Center for Biotechnology Information at the U. S. National Library of Medicine NCBI/NLM.

    Chloroquine-induced pruritus