Non aqueous titration of chloroquine

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  1. gendncc XenForo Moderator

    Non aqueous titration of chloroquine


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Non-aqueous solvents are used in titration of very weak acids and bases. This is to combat the effects of water which also acts as a weak acid and base. Asked in The Difference Between Dissolve a quantity of the substance being examined to give an expected titration volume of between 70–90% of the burette volume, in 50 mL of dehydrated ethanol R and 5.0 mL of hydrochloric acid 0.01 mol/L VS. Carry out a potentiometric titration 2.6. Non-aqueous titration 2017-01 Page 1 of 2 The International Pharmacopoeia - Ninth Edition. Jan 23, 2018 Non Aqueous Titrations, Acidimetric Titrations, Alkalimetric Titrations.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Non aqueous titration of chloroquine

    Application of Derivative Spectrophotometer for Analysis of., Non-aqueous titration - World Health Organization

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  6. The nonaqueous titrimetric method was applied as parallel validation estimation. This involves volumetric determination of the chloroquine in non- aqueous solvent using 0.1M perchloric acid and crystal violet as indicator.

    • International Journal Of.
    • Part 4 Non Aqueous Titrations - Acidimetry and Alkalimetry..
    • CHAPTER 8 SPECTROPHOTOMETRIC ASSAY OF CHLOROQUINE PHOSPHATE.

    Naiman Abstract The author discusses reasons for variations in the solubility products of silver chromate and silver chloride. The non-aqueous titration of the salts of weak acids Journal of Chemical Education. Latimer Abstract A method for the HClO4 titration of the salts of carboxylic acid in glacial acetic acid. HCl in acetic acid—weakly acidic. Acetic acid in water—weakly acidic. Acetic acid in ammonia—strongly acidic. The acids that are titrated by the non-aqueous titration are acid halides, acid anhydrides, carboxylic acids, and amino acids and enols such as xanthenes, imides, phenols, pyrroles, and sulfonamides. Nonaqueous titration is the titration of substances dissolved in solvents other than water. It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent in which organic compounds are soluble. The most commonly used procedure is the titration of organic bases with perchloric acid in anhydrous acetic acid. These assays sometimes take some perfecting in terms

     
  7. sunapse XenForo Moderator

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. Chloroquine, an old malaria drug, may help treat. Aralen, Chloroquine phosphate chloroquine dosing. CHLOROQUINE PHOSPHATE, USP - Food and Drug Administration
     
  8. VsexLove Guest

    Ideal Body Weight for Calculating Hydroxychloroquine Dosage Ideal Body Weight for Calculating Hydroxychloroquine Dosage. The most important risk factor for hydroxychloroquine retinopathy is the daily dose of the drug. If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range /= 6.5 mg/kg/day.

    Great Debate examines questions about hydroxychloroquine.